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February 18, 1998

Prostate Cancer Potentially Linked to the HPC1 Gene

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(7):507-508. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-7-jbk0218

To the Editor.— I disagree with the conclusions of the article by Dr Grönberg and colleagues1 on the characteristics of prostate cancer in families potentially linked or potentially unlinked to the hereditary prostate cancer 1 (HPC1) gene.

First, on comparing the tumor stage in families potentially linked and those not shown to be linked, the authors state there is higher-stage disease with HPC1 linkage. This statement is based on a comparison with a reference population from the National Cancer Database but not with the unlinked families. When the linked and unlinked families are compared, there is no difference (P=.16, Fisher exact test).