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February 25, 1998

Emerging Drug Resistance and Vaccination for Typhoid Fever—Reply

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;279(8):579-580. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-8-jbk0225

In Reply.—Antimicrobial resistance in S typhi and vaccinology have developed rapidly in recent years. Drs Atkins and Gottlieb point out that quinolone resistance to S typhi is an evolving problem in South Asia and that susceptibility testing should be performed. In the United States, the standard of care is to determine susceptibility for blood isolates. However, these developments emphasize the need for antimicrobial surveillance in areas where testing is not routine and where quinolones are routinely used. For the patient we presented at Grand Rounds, quinolones were not an option because of pregnancy.

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