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March 11, 1998

Antibiotic Therapy for Premature Rupture of Membranes to Prevent Respiratory Distress Syndrome

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(10):748-749. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-10-jac80000

To the Editor.—Dr Mercer and colleagues of the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network1 have recently recommended that women with expectantly managed preterm premature rupture of membranes (PPROM) remote from term (≤32 weeks) should receive a specific regimen of antimicrobials to reduce infant morbidity. Whereas we applaud their efforts, we cannot agree that the conclusion should necessarily follow from their results given contemporary perinatal practice.