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Asymptomatic gastroesophageal reflux (GER) is prevalent in children with asthma, and untreated GER has been postulated as a cause of poor asthma control. Investigators from 19 American Lung Association Asthma Clinical Research Center sites randomly assigned 306 children with poor asthma control despite inhaled corticosteroid treatment and without symptomatic GER to receive either the proton pump inhibitor lansoprazole or placebo for 24 weeks. The investigators report that compared with placebo, lansoprazole was not associated with improvement in asthma symptoms or lung function but was associated with an increase in adverse events. In an editorial, Martinez discusses the lack of evidence supporting the role of GER in asthma pathogenesis and consequences of therapeutic creep.
This Week in JAMA. JAMA. 2012;307(4):335. doi:https://doi.org/10.1001/jama.2012.3
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