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October 24, 1931


JAMA. 1931;97(17):1230. doi:10.1001/jama.1931.02730170042017

Evidence is gradually accumulating to indicate that dietary essentials which are present in presumably adequate amounts in the food may nevertheless escape proper utilization in the body, so that nutritional failure may ensue. There have been instances of threatened xerophthalmia, for example, which have not been cured by feeding cod liver oil or other sources of vitamin A, because of alimentary conditions that interfered with the absorption of the essential food factor. Relief was brought about by parenteral administration of products bearing vitamin A. Something analogous to this was referred to at the Philadelphia session of the American Medical Association in relation to the liver treatment of pernicious anemia. Castle and his associates4 of the Harvard University Medical School reported a significant study of two patients, one of whom was relatively unaffected by the daily ingestion of the extract prepared from 300 Gm. of liver and the other by