The volume of the circulation is the size of the blood stream pumped through the lungs and out to all the organs of the body by the heart. It is not the same thing as the total blood volume of the body. The blood volume is measured simply in liters or in liters per kilogram of body weight. The volume of the circulation is measured in liters of blood flow per minute.
It is merely a coincidence that in a resting man of average size the heart pumps each minute a volume which is about equal to all the blood in the body.1 In small animals, with their high metabolism, the heart beats so rapidly and the volume of the circulation is so large that, as an average, each particle of blood goes round the circulation two or three times each minute. In large animals the heart beats more
HENDERSON Y. THE VOLUME OF THE CIRCULATION AND ITS REGULATION BY THE VENOPRESSOR MECHANISM. JAMA. 1931;97(18):1265–1269. doi:10.1001/jama.1931.02730180001001
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