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October 31, 1931


JAMA. 1931;97(18):1275-1279. doi:10.1001/jama.1931.02730180011004

A laboratory procedure for the diagnosis of pregnancy has been a subject of interest to obstetricians for many years. The early work in this field, which seemed most promising at first, has been shown to have little or no practical value. Since then, advances in physiology and endocrinology have added much to our knowledge of the function of the ductless glands and of their physiologic changes during pregnancy. It is on this fundamental work that the pregnancy tests of Aschheim and Zondek, of Brouha and of Friedman depend. In this study these three reactions, as well as the empiric reactions of Bercovitz and of Manoilov, have been performed, so far as possible, on each individual in a series of pregnant and nonpregnant patients. It is our purpose to ascertain their relative values as diagnostic procedures in gynecologic as well as obstetric cases.

A large amount of experimental work has been

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