Our purpose in this study was to determine any changes that might be present in the blood, pus, tissue or bone wall of diseased sinuses, more especially in chronic sinus disease. It was hoped by this investigation to reveal, through the biochemical observations, information which would be of importance pertaining to the diagnosis, prognosis and treatment. It was thought also that it might be the means of determining the extent of involvement and chronicity.
In this study, only patients with definite and unmistakable evidence of a sinus disease were selected. The examination of the patients consisted of the history, rhinoscopic examination, roentgenograms of sinuses, and, when indicated, resort to direct irrigation of the sinus, chemical analysis of the blood, Kahn and Wassermann tests, and urinalyses. The patients were from 4 to 64 years of age. The Caldwell-Luc operation was utilized in the radical cases when the maxillary sinus was opened.
ISRAEL S, NICHOLAS HO. THE BIOCHEMICAL STUDY OF SINUS DISEASE. JAMA. 1931;97(20):1453–1456. doi:10.1001/jama.1931.02730200029006
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