In September, 1928, I1 emphasized the fact, previously noted by Wagner von Jauregg,2 that, although treatment by malaria is the most effective form of treatment for patients suffering from dementia paralytica, the ideal time to apply the treatment is before the paresis develops. I suggested then that the patient with paresis sine paresi is the ideal candidate for such treatment. Paresis sine paresi includes that phase of neurosyphilis which is sometimes designated as impending paresis, a status in the course of the disease when the clinical signs suggest parenchymatous involvement of the nervous system but are not conclusive enough to warrant such a diagnosis. However, the reactions of the spinal fluid in paresis sine paresi, because of resistance to treatment and the fact that the disease has maintained the paretic characteristics for a long time, permit such cases to be classified distinctly although temporarily. Obviously, it is a
O'LEARY PA. TREATMENT BY MALARIA IN ASYMPTOMATIC NEUROSYPHILIS. JAMA. 1931;97(22):1585–1587. doi:10.1001/jama.1931.02730220007002
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