By far the greatest percentage of cases of cancer of the cervix uteri is diagnosed only when the disease is already more or less far advanced. Even in the so-called early cases, the pathologic process is quite well established and has made some inroads. The consensus is that the outlook for the patient improves, the earlier the stage in which the cancer is discovered. One must try, therefore, to detect cancer at a still earlier, in fact, at its earliest stage, and, if possible, go even beyond this to the precancerous condition which may give rise to malignant degeneration. Of such precancerous conditions which are potentially dangerous, several are known; for instance, cervical tears, erosions, eversions and leukoplakias. The last named condition, although its relation to cancer of the cervix has been known through von Franqué and others for more than thirty years, has received far too little attention on
EMMERT F. THE RECOGNITION OF CANCER OF THE UTERUS IN ITS EARLIER STAGES. JAMA. 1931;97(23):1684–1688. doi:10.1001/jama.1931.02730230026006
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