Most textbooks of physiology and biochemistry are singularly silent about the synovial fluid and its origin. Yet this substance is of unquestionable moment to the body in providing assurance of comfort in the movement of joints. It often presents pathologic considerations that are quite tantalizing to the physician who is compelled to deal with them therapeutically. The synovial fluid is sometimes grouped with transudates and exudates that occur in various parts of the body, notably with such fluids as peritoneal or pleural effusions. The composition of the synovia is not constant but differs in rest and motion of the joints that it bathes. There is a notable distinction between the fluid and blood plasma or ordinary lymph, presumably due to a mucin-like substance in the synovia. This serves to explain the wide difference in fluidity and stickiness of fluids within joints which is not commonly encountered in plasma. The exact
SYNOVIAL FLUID. JAMA. 1931;97(26):1969. doi:10.1001/jama.1931.02730260035014
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