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December 26, 1931


JAMA. 1931;97(26):1976-1977. doi:10.1001/jama.1931.02730260042021

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Recurrent Fever Substituted for Malaria in Treatment of Dementia Paralytica  Mr. Auguste Marie, who was one of the first in France to treat dementia paralytica by inoculation with malaria, is endeavoring to substitute for the plasmodium of malaria the spirillum of recurrent fever, which provokes the same manifestations of hyperthermia, and he has recently communicated to the Academy of Medicine the results of his observations. He presents this method rather as supplementary to the malaria method. The results obtained were less sure; but recurrent fever therapy appears to him indicated in some instances when malariotherapy is not applicable; for example, in persons who had malaria in childhood, or in dementia paralytica in which malaria has been employed but which shows a recrudescence. In such cases, attempts to reinoculate malaria often fail. To get around immunity that might be a contraindication to reinoculations of recurrent fever, it is sufficient to alternate

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