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January 16, 1932

Experimental Studies on the Course of Paratyphoid Infections in Avitaminotic Rats with Special Reference to Vitamin A Deficiency.

JAMA. 1932;98(3):254. doi:10.1001/jama.1932.02730290070032

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The author starts with the same thesis that every deficiency of nutrition, whether of quantitative or qualitative nature, is accompanied by an increased susceptibility to infection and a lowered resistance. On the basis of a detailed review of the observations now available, the author concludes that "the rôle of vitamin A as an anti-infectious factor appears indisputable; that vitamin B is hardly playing any rôle in this respect; that the opinions as to the importance of vitamin C in this respect are divergent, though it is most likely that this vitamin is hardly of any particular importance to the organism as far as resistance to infection goes; and, finally, that there is nothing directly suggestive of vitamin D having any resistance-increasing effect, and that for that matter the clinical material is less suitable for information on this point than is the clinical material concerning the other vitamins." He points out

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