Hyperthyroidism is characterized by an increased total heat production by the animal organism. The exact source of the energy that goes into the production of this excess heat is obscure. Carbohydrates are in normal individuals an important source of heat production. In hyperthyroidism the glycogen content of the liver is greatly depleted if not completely exhausted, as shown by Schryver1 and by Cramer and Krause,2 and yet in this condition many investigators have observed a reduced sugar tolerance. Sanger and Hun3 believed that this indicated an inability of hyperthyroid patients to store glycogen in the liver. Du Bois,4 however, reports an experiment on a hyperthyroid patient which indicated that storage of carbohydrate in the liver did occur. Boothby and Sandiford5 as a result of extensive experiments, concluded that "there is no measurable increase in the endogenous protein metabolism in exophthalmic goiter; therefore it cannot be
SIMONDS JP, HELPLER OE. FAT TOLERANCE IN EXPERIMENTAL HYPERTHYROIDISM. JAMA. 1932;98(4):283–284. doi:10.1001/jama.1932.02730300013003
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