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Reinforcement of the Action of Antitetanic Serum
Antitetanic serum, while its preventive action is well established, is weak against tetanus that has progressed farenough to be diagnosed clinically. Dufour has greatly increased its action by his method, which is coming more and more into vogue in France and which consists in plunging the subject for twenty minutes into chloroform anesthesia after intravenous and intraspinal injection of the serum. The intervention can be repeated without danger for several days in succession, if necessary. It would seem that chloroform and ether, whose action on the lipoids of the brain has been invoked to explain their anesthetic effects, liberate the tetanic antitoxin from its union with the nerve cell and thus greatly increase its influence on Nicolaier's bacillus. Mr. Coudy of Marseilles has reported to the Academy of Medicine that he secured equally good results by adding to the antitetanic serum not an
PARIS. JAMA. 1932;98(5):413–414. doi:10.1001/jama.1932.02730310053021
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