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January 30, 1932

Bendien's Diagnostic Methods for Cancer and Principles of Treatment.

JAMA. 1932;98(5):423. doi:10.1001/jama.1932.02730310063034

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The author reflects Dr. Bendien's views and theories on cancer, emphasizing the necessity of two factors in the development of malignant disease: an exogenous factor (chronic irritation) and an endogenous factor in the form of cancer susceptibility. The existence of an immunizing factor is believed to counteract the development of cancer. In Bendien's flocculation test the precipitate consists of (1) a special thermostable protein formed as the result of cancer metabolism and (2) a protein which dissolves when heated to 56 C. for thirty minutes (normallabilin). Bendien's test consists of precipitation of the blood serum, optical examination of the precipitate and observing the nature of the colloidal charge of the serum protein. The test is described in detail. Normallabilin is believed to have a profound influence on the cancer process. Its quantity can be measured. Unlike antitoxin, it is not regarded as specific. Its presence indicates a resistance against the

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