The reliability and safety of intravenous urography were studied in 654 patients. The injection consisted of 25 cc. of Renografin (a 60% aqueous solution of the methylglucamine salt of 3,5-diacetylamido-2,4,6-triiodobenzoate) given over a period of three minutes; in only three cases were smaller doses used. There were no severe reactions, but vomiting occurred in 11 patients. One of these had a history of allergy, and another had not been properly prepared. The low incidence of reactions was striking because the ages of the patients ranged from 7 to 84 years and 16 had histories of allergy or severe reactions to previously administered contrast agents. Satisfactory roentgenograms of the kidneys were obtained in 636 (97%) of the cases, demonstrating the great diagnostic value of this procedure.
Orr LM, Campbell JL, Thomley MW. INTRAVENOUS UROGRAPHY WITH RENOGRAFIN 60%: A REPORT OF MORE THAN 600 CASES. JAMA. 1959;169(11):1156–1158. doi:10.1001/jama.1959.03000280008003
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