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April 22/29, 1998

False-Negative Qualitative Troponin T

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(16):1262-1263. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-16-jac80007

To the Editor.—Dr Mahalingam and Ottlinger1 report the case of an elderly patient with angina pectoris on exertion associated with discrepancies in laboratory values comprising an increase in quantitative cardiac troponin T (cTnT) and in total and MB creatine kinase (CK) and a negative result for cTnT rapid test. They conclude that the cTnT rapid test failed to diagnose myocardial infarction in this patient. However, we propose another hypothesis: that the patient had no myocardial infarction but only a macro CK in his serum.