The effectiveness of cortisone in preventing esophageal stenosis after ingestion of lye in rabbits suggested the use of steroids for the prevention of stenosis in children who have swallowed lye. Prednisone was administered to 13 children who had swallowed lye. The data are summarized. In three cases which are described in detail the lye was strong enough to cause visible lesions in the mouth. The dosage of prednisone was 10 mg. each six or eight hours for periods up to 16 days, with tetracycline to prevent infection. Neither infection nor stricture appeared in any of the 13 children. Although the treatment with steroids appeared to be effective, the real answer lies in the prevention of accidents with lye.
Miller CL, Warren ROY. STEROID TREATMENT OF LYE BURNS OF THE ESOPHAGUS. JAMA. 1959;170(13):1525–1527. doi:10.1001/jama.1959.03010130029007
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