Up to 1917, when Wagner-Jauregg presented his remarkable results in the treatment of dementia paralytica with malaria, the prognosis was extremely poor. This new form of treatment was soon instituted by others, who corroborated his observations as the years went by. O'Leary and Welsh1 reported similar results at the Mayo Foundation. One of us,2 reporting the observations in this clinic, found similar results.
The prognosis in juvenile dementia paralytica has been considered more unsatisfactory than in dementia paralytica. Almost as soon as malaria and other forms of fever therapy were used in adult dementia paralytica, it was tried in the juvenile type. O'Leary and Welsh1 reported little if any improvement. Though the consensus is that the prognosis in the juvenile type is almost as poor today as it was before 1917, very little has been written on the malaria treatment of this condition.
There were seen in
WILE UJ, HAND EA. JUVENILE DEMENTIA PARALYTICA: WITH SPECIAL REFERENCE TO ITS TREATMENT WITH MALARIA. JAMA. 1935;105(8):566–567. doi:10.1001/jama.1935.02760340012005
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