It has been recommended1 that cevitamic acid, when administered parenterally, be dissolved in distilled water and neutralized with one-half its quantity of sodium bicarbonate in order to avoid tissue sloughing. Another note of caution appears to be warranted in connection with its intravenous use. A patient was given 100 mg. of cevitamic acid N. N. R. dissolved in 10 cc. of sterile distilled water by vein and had a chill immediately after the injection, followed by fever and general discomfort. The reaction was thought to be due to the hemolytic effect of the acid, since blood aspirated into the syringe containing the drug solution was laked immediately. This prompted an inquiry into the hemolytic action of neutralized and unneutralized cevitamic acid dissolved in either physiologic solution of sodium chloride or distilled water.
Briefly, it was noted that concentrations of 1: 1,000 or stronger of natural or synthetic
Anderson HH, Leake CD. HEMOLYTIC ACTION OF CEVITAMIC (ASCORBIC) ACID. JAMA. 1935;105(13):1033. doi:10.1001/jama.1935.92760390004008d
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