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September 28, 1935


JAMA. 1935;105(13):1057. doi:10.1001/jama.1935.02760390051025

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To the Editor:—  In the article by Dr. Herman O. Mosenthal on "Hyperglycemia: Evaluation in the Treatment of Diabetes," in The Journal, August 17, the statement is made by him and most of those who discussed the paper that diabetes is a contributing factor in the causation of arteriosclerosis. I believe Dr. Joslin is the most important sponsor for this view. It is rather curious that in the study of arteriosclerosis most observers have overlooked a rather simple observation, which completely disproves any metabolic origin in the causation of arteriosclerosis; namely, the complete independence in the incidence of arteriosclerosis between the general and pulmonary circuits (Moschcowitz, Eli: The Cause of Arteriosclerosis, Am. J. M. Sc. 178:244 [Aug.] 1929). A false perspective is given to the study of human arteriosclerosis when observations are confined, as is conventionally done, to the aorta and its branches. If, however, observations on the aorta

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