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Article
October 5, 1935

FUNCTIONAL STUDIES IN PATIENTS WITH THE NEURODERMATOSES

JAMA. 1935;105(14):1098-1103. doi:10.1001/jama.1935.02760400014004
Abstract

Increased interest is being evinced in so-called functional medicine by workers in all branches, and the functional approach as contrasted to and supplemental to but not as a substitute for the mechanistic approach is being taught more and more to undergraduate and postgraduate students of medicine. One of us,1 on the basis of intensive study of the patients themselves, has suggested the classification of certain dermatoses as neurodermatoses, since they are always found in patients with neurocirculatory instability. Stokes2 prefers the term "diathetic makeup," and adds: "One might call it 'neurodermobronchionasomucosal lability' without having named all the elements involved. This state of inborn tissue lability and hyperirritability is hereditary in character." As we shall state later, we believe that the term "protoplasmic instability" expresses our conception of the condition.

Careful study of patients has convinced us that an underlying instability is present and plays an important rôle in

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