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October 12, 1935


JAMA. 1935;105(15):1168-1172. doi:10.1001/jama.1935.02760410012004

Diabetes mellitus has definitely increased during the last decade. With the increasing incidence of this disease there has come a greater appreciation of its symptoms and the symptoms of its complications. The disease as well as some of its complications has been named from syndromes which are merely terminal manifestations. In most instances, long before the development of the advanced stages, symptoms have been present which if properly interpreted will enable one to make an earlier diagnosis and in many cases prevent a development of serious and even fatal sequelae.

Thus the symptoms of polyuria and polydipsia from which diabetes has derived its name have developed in only a relatively small percentage of cases when first seen. It is now realized that diabetic gangrene in the vast majority of cases is a terminal condition, the result of definite arterial changes, which many years before the development of gangrene give premonitory