The development of information concerning anemia during the past decade has permitted the clear recognition that this condition often may be dependent on defective or deficient nutrition. This idea, however, is not new; for example, in 1651 was written by an anonymous author "[Chlorosis is] chiefly found in young maidens who... foolishly feed upon trash." Wide gaps in our knowledge remain and complete information concerning the mechanism of producing anemia associated with nutritional deficiency must be obtained in the future, but at present one can recognize that anemias may arise because of a lack or nonavailability in the body of at least three classes of dietary substances: (1) iron, (2) vitamin C and (3) a mysterious substance contained abundantly in liver and, to a less extent, in certain other organs which, if absent, makes normal blood formation impossible, and anemias of the so-called pernicious type ensue.
The anemias due
MINOT GR. THE ANEMIAS OF NUTRITIONAL DEFICIENCY: ETIOLOGY, DIAGNOSIS, TREATMENT AND PREVENTION. JAMA. 1935;105(15):1176–1179. doi:10.1001/jama.1935.02760410020006
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