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Article
October 12, 1935

THE ANTIGENIC VALUE OF VARIOUS PREPARATIONS OF DIPHTHERIA TOXOID: A COMPARATIVE CLINICAL STUDY

JAMA. 1935;105(15):1182-1183. doi:10.1001/jama.1935.02760410026008
Abstract

Since 1929 diphtheria toxoid has been used in the immunization of nurses at the Cook County Hospital. Many of the nurses in this group are either in the post-graduate school or come from affiliated schools for the contagious or pediatric service. The time for immunizing them is therefore limited. It is important also that the immunization interfere as little as possible with their training school courses. Because of reactions observed at times in adults on the administration of toxoid, it has been found advisable to give an initial dose of 0.1 cc. followed at weekly intervals by 0.25 cc., 0.5 cc., 1 cc. and from 1.5 to 2 cc. The small initial doses probably in most instances confer little immunity but may serve to desensitize the individual to the proteins contained in the toxoid mixture so that the larger doses can be tolerated with less reaction. Retests are made after

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