Recently, within a comparatively short period, autopsies revealed esophageal carcinoma in four patients who had not presented dysphagia, pain, regurgitation of food and vomiting, the characteristic symptoms. In the absence of the usual clinical picture presented by the disease, their physicians had not appreciated the presence of a new growth in the esophagus; they found some consolation for their failure in diagnosis, however, in the fact that the postmortem examination presented carcinomatous lesions which were nonstenosing and therefore did not obstruct the passage of food.
The evidence in these four cases prompted the undertaking of a clinicopathologic analysis of the Philadelphia General Hospital series of patients from 1920 to 1933. It was hoped that such a study might point the way to certain conclusions concerning the incidence of nonobstructive carcinomatous lesions in the esophagus, that distinguishing clinical evidences might be brought to light, that the relative degree of clinical and
MATHEWS RW, SCHNABEL TG. PRIMARY ESOPHAGEAL CARCINOMA, WITH ESPECIAL REFERENCE TO A NONSTENOSING VARIETY: A CLINICOPATHOLOGIC STUDY BASED ON ONE HUNDRED AND EIGHT NECROPSIES. JAMA. 1935;105(20):1591–1595. doi:10.1001/jama.1935.02760460027006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: