In 1933 soluble saccharin (sodium orthosulphinidbenzoate) was introduced by Fishberg and his associates1 as a means for measuring the circulation time. A year later Hitzig2 introduced ether to measure the efficiency of the right heart. The combination of these two methods has been popularly designated as the saccharin-ether test for circulation time. In both of these communications the authors stress the safety and lack of both local and systemic reactions. It is my purpose to report two serious accidents following the use of this test.
Saccharin Method : Three grams of soluble saccharin is placed in a dry tube and autoclaved for ten minutes; then 3 cc. of sterile triple distilled water is added and the mixture is gently heated until the solution is completed. This is allowed to cool, and 2.5 cc. is injected intravenously through a number 19 gage needle as rapidly as feasible. The time
Leinoff HD. COMPLICATIONS FOLLOWING USE OF SACCHARIN AND ETHER AS A CIRCULATION TIME TEST. JAMA. 1935;105(22):1759. doi:10.1001/jama.1935.92760480002007a
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