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December 14, 1935


Author Affiliations


From the Department of Urology, the Memorial Hospital.

JAMA. 1935;105(24):1965-1972. doi:10.1001/jama.1935.02760500017004

This paper is a clinical study based on the records of 292 patients with testicular teratomas. It is presented at this time because the increased number of patients permits better evaluation of radiation therapy in this disease and because there have been recent improvements in diagnostic and therapeutic procedures.

PATHOLOGIC ANATOMY  The natural history of the disease must be understood before testicular teratomas can be properly managed. Much is still unknown regarding the origin of these tumors. Ewing's theory probably has widest acceptance. He believes that all teratomas arise from sex cells, most frequently situated in the rete testis but sometimes present in the tunica albuginea. The sex cells are totipotent and for this reason may produce any of the tissues derived from the three primary germ layers. There seems to be a tendency for one type of tissue to outgrow the others, because in most tumors either one tissue