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December 14, 1935

Pellagroide Dermatosen an Geisteskranken mit besonderem Hinblick auf das Vorkommen solcher bei Schizophrenen und mit Beiträgen zur Beleuchtung gewisser ätiologischer und pathogenetischer Verhältnisse bei Dementia praecox und Pellagra

JAMA. 1935;105(24):2012. doi:10.1001/jama.1935.02760500064033

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Abstract

This is a clinical study of 955 mental patients in a Denmark asylum, in 182 (19.3 per cent) of whom pellagroid skin lesions were found, mainly of a hyperkeratotic type on the elbows, knees, hands and face. The highest incidence was seen in the encephalitis cases (60 per cent), next in the schizophrenic group (21 per cent) and third (8.6 per cent) in the manic depressive class. Fourteen cases were considered to be true pellagra on account of the association of a severe dermatitis with stomatitis, diarrhea and neurologic symptoms. Other skin disorders, such as acne and rosacea, were frequently found in the dementia praecox group. As controls, 881 criminals in the state prison were investigated to determine the effect of a low vitamin diet on the frequency of skin changes, and only 4.5 per cent were found to have pellagroid dermatoses. Investigations of the gastric contents and blood changes

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