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January 25, 1936

ADDISON'S DISEASE FOLLOWING ADRENAL DENERVATION: IN A CASE OF DIABETES MELLITUS

JAMA. 1936;106(4):279-281. doi:10.1001/jama.1936.02770040019005
Abstract

This case is reported primarily to illustrate the possible serious consequences of adrenal surgery as a therapeutic procedure. For a number of years I have maintained that, with the possible exception of adrenal neoplasm, present knowledge of these glands does not warrant surgical intervention with them as a means of treating disorders elsewhere. Every investigator experienced in experimental work on the adrenals in animals is familiar with the great risk to life that attends operations on these organs. Nevertheless, there appears to be an increasing tendency, on the part of surgeons, to operate on the adrenals or their nerves for the relief of various diseases. This is done on the assumption that these glands, especially by their secretion of epinephrine, play a significant rôle in those conditions. Such an assumption, however, does not have the support of indisputable experimental or clinical evidence.

In the case that is reported here briefly,

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