Adequately financed group investigation frequently yields practical results of great benefit to mankind. The information compiled in Puerto Rico by the members of the Commission of the Rockefeller Foundation for the Study of Anemia, supplemented by animal experimentation at the Hospital of the Rockefeller Institute for Medical Research in New York, is an example of the value of such well organized investigation. The data on the etiology and treatment of sprue 1 are now available, particularly as they concern the conflict between the infectious and the deficiency theories of its causation. The study included careful observations of approximately ninety patients in Puerto Rico, supplemented by special studies of patients at the Thorndike Memorial Laboratory of the Boston City Hospital. Subsequent experiments on animals also are reported.
The blood picture in sprue has frequently been described and the resemblance of the macrocytic anemia to pernicious anemia pointed out. The disturbances of
ETIOLOGY AND TREATMENT OF SPRUE. JAMA. 1936;106(5):385–386. doi:10.1001/jama.1936.02770050041014