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A human strain of Endamoeba histolytica retained its virulence after having been transferred for eight years, intrarectally, from kittens to kittens, from kittens to dogs, and vice versa. Similarly, cultures of Endamoeba histolytica failed to lose their virulence. In kittens the disease ran a rapid course, with incubation period very short, about two days, in the majority of cases, followed by a bloody diarrhea, loss of weight and appetite, and finally death after several days. Ninety per cent of the young kittens died within five days after onset of the symptoms. Older heavier cats were less frequently infected and lived longer. Old heavy cats occasionally recovered spontaneously. Of 1,553 infected cats, forty-three recovered spontaneously. Young kittens never recovered spontaneously. Young puppies (60 per cent from 2 to 3 months old) were more easily infected than old dogs, which recovered spontaneously. With the increase in age and size dogs become more
Experimentelle Untersuchungen über Amöbenruhr. I. Teil: Krankheitsverlauf bei kũnstlicher und spontaner Übertragung der Amöbiasis. JAMA. 1936;106(8):650. doi:10.1001/jama.1936.02770080064035
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