Nonsuppurative encephalitis, first described by Barlow and Penrose1 in 1887, has been comparatively rare until within the last decade. Most of the cases reported have appeared during the past seven or eight years. It has been suggested by Neal and Appelbaum2 that the increased incidence of this condition may be due to a greater interest on the part of the physician.
The condition occurs during or following the acute exanthematous diseases, especially measles, dysentery, typhus, pneumonia, influenza, herpes, postvaccinal diseases and exogenous poisons, such as arsenic, lead and alcohol; and recently Winkelman and Eckel3 reported five cases complicating acute rheumatic fever. Barker4 has described the so-called hemorrhagic encephalitis as an acute condition occurring suddenly in previously healthy young persons.
No definite statement can be made concerning the etiology. Actual microbic invasion of the brain has not been found. Levaditi5 and Pette6 believe the condition
SHAFER RJ. NONSUPPURATIVE ENCEPHALITIS: REPORT OF FIVE CASES. JAMA. 1936;106(9):699–701. doi:10.1001/jama.1936.02770090035010
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