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February 29, 1936

ROLE OF BILE IN VITAMIN A UTILIZATION

JAMA. 1936;106(9):709. doi:10.1001/jama.1936.02770090045016
Abstract

Much evidence is available emphasizing the rôle of bile in the absorption of lipids;1 little or none of this foodstuff is absorbed when bile is excluded from the intestinal tract. This decreased absorption of the lipids is significant first with respect to the requirement of the organism for this material for purposes of energy. It assumes added importance when considered from the point of view of water-insoluble substances that depend on fat as a vehicle for transport across the intestinal wall. Decreased absorption of cholesterol, for example, has been noted in icteric patients and is apparently associated with a diminished absorption of fat. Whether the bile aids the absorption of cholesterol by direct solvent action on this sterol or by an indirect assistance through its effect on fat (a solvent for cholesterol) is not entirely clear. The fact remains that bile influences the absorption of lipids and of materials

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