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March 7, 1936


Author Affiliations

Assistant Superintendent, St. Peter State Hospital ST. PETER, MINN.

JAMA. 1936;106(10):775-777. doi:10.1001/jama.1936.02770100023008

It is generally thought that tertian malaria transmitted by direct blood inoculation is easily cured by quinine. According to James,1 "clinically there is a striking difference between the two classes in that true (long interval) relapses and recurrences are not observed (so far as we can ascertain) in inoculated cases, while they occur in 50 per cent of mosquito infected cases." He adds that blood inoculated cases are cured by a single short course of quinine. Yorke2 concurs in this view, saying "it is an established fact that two or three doses of quinine almost invariably suffice definitely to cure the inoculated case." Wagner-Jauregg3 relates that in Vienna, where more than 6,000 patients have been treated, no case of recidivation has been noted. He considers 5 Gm. of quinine, given in the course of a week, sufficient to cure the disease.

Although few in number, recurrences have