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March 7, 1936


JAMA. 1936;106(10):777-779. doi:10.1001/jama.1936.02770100025009

In the therapy of coccidioidal granuloma numerous agents have been suggested since the first case was described by Rixford1 in 1894. He used potassium arsenite, potassium iodide and yellow mercurous iodide internally and iodine, bromine, phenol, methyl violet, turpentine and mercury bichloride locally, without success. Subsequent writers have run the gamut of chemical, physical and immunologic agents. Montgomery and Ormsby2 recommended general supportive measures, as in the therapy of tuberculosis. Brown,3 Brown and Cummins4 and Burgess5 have suggested the use of iodides, and Cooke6 has suggested their use in conjunction with arsphenamine.

Antimony in the form of antimony and potassium tartrate has been used by a number of investigators. Guy and Jacob7 used it in conjunction with x-rays with apparent success but were unable to carry out animal experiments owing to the peritonitis developing from the injection of antimony and potassium tartrate, an