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March 14, 1936


JAMA. 1936;106(11):916. doi:10.1001/jama.1936.92770110001012

Since Angelus Sala in 1647 first reported a case of argyria, accounts of a similar nature have been by no means uncommon. However, a case in which argyria seemed to become manifest because of pregnancy presented a problem in physiochemistry worthy of consideration and report.

A woman, aged 47, admitted to the clinic Aug. 23, 1935, complained of gas on the stomach, abdominal distention, and discomfort in the right upper quadrant of the abdomen. It was found that she had gallstones ; subsequently cholecystectomy was performed and was followed by uneventful convalescence.

The features in this case that we wish to consider were in no way related to the diseased gallbladder. Although the patient made no complaint of the peculiar color of her skin, we were immediately struck by the condition. On inquiry, she gave the following story :

Fifteen years before, she had undergone tonsillectomy. Following the tonsillectomy she had sprayed her