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March 21, 1936

The Spleen and Resistance

JAMA. 1936;106(12):1035. doi:10.1001/jama.1936.02770120067038

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One of the factors that determine the infectibility as well as the sequelae of infections in the human body has been constantly associated with the spleen and the reticulo-endothelial system. A fair amount of medical literature has been devoted to this interesting but evasive subject. The authors of this monograph have not only critically evaluated that literature but cite their own contributions in detail, which definitely add to our knowledge. Human as well as animal material has been utilized for study. The introductory chapter on anatomic considerations of the spleen is concise but adequate. Then follows a detailed consideration of the pathologic changes in the spleen in various types of infections of bacterial, virus, parasite and fungus origin. The functions of the spleen as an organ of macrophage tissue and antibody formation are next discussed and this material is correlated with changes after splenectomy. Each phase of the subject and

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