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March 28, 1936

SENSITIZATION OF GUINEA-PIGS WITH METHYL HEPTINE CARBONATE

JAMA. 1936;106(13):1112. doi:10.1001/jama.1936.02770130062028

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Abstract

To the Editor: —  Prompted by a recent editorial comment (Lip Stick Dermatitis, The Journal, February 8, p. 470) we report briefly experiments which have shown that sensitization of animals with methyl heptine carbonate can be effected by methods used in previous work on dinitrochlorobenzene and other substances (Landsteiner, Karl, and Jacobs, John: Studies on the Sensitization of Animals with Simple Chemical Compounds, J. Exper. Med.61:643 [May] 1935). The investigation was made on account of observations in human beings on dermatitis due to facial cream or lip stick containing methyl heptine carbonate and "perfume dermatitis" described in papers first brought to our attention by Dr. Simon Flexner (Hoffman, M. J., and Peters, John: Dermatitis, Due to Facial Cream, Caused by Methyl Heptine Carbonate, The Journal, March 30, 1935, p. 1072. Baer, H. L.: Perfume Dermatitis, ibid., May 25, 1935, p. 1926).Ten intracutaneous injections at weekly intervals in

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