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This small monograph summarizes the highly creditable research work of the author and his collaborators on the rhythmic nature of liver function. They have found that during the twenty-four hours of each day the liver passes through two opposing phases or cycles of function. Each cycle begins where the other leaves off, rises to a climax and gradually subsides, to merge into the initial stage of the other cycle. These cycles may be called the assimilatory and the secretory phases respectively, and they vary as regards the time of occurrence in different species and even in different individuals of the same species. In man the assimilatory phase usually occupies the hours between 8 p. m. and 8 a. m., while the secretory phase occurs between 8 a. m. and 8 p. m. During the former phase the liver stores glycogen, water and protein and becomes correspondingly larger and heavier. Its
Über die Rhythmik der Leberfunktion, des Stoffwechsels und des Schlafes. JAMA. 1936;106(13):1120. doi:10.1001/jama.1936.02770130070038
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