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April 11, 1936


JAMA. 1936;106(15):1331. doi:10.1001/jama.1936.02770150091025

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To the Editor:—  Dr. M. C. Petersen in a recent article (The Journal, March 7, p. 775) refers to the "recurrence of inoculation malaria." This emphasizes the importance of using a malarial strain in which no sexual forms of the parasite are found. In a series of articles published in the American Journal of the Medical Sciences176:664 (Nov.) 1928, 179:800 (June) 1930 and 184:262 (Aug.) 1932, my associates and I have shown that approximately two and a half years is required to obtain a true biologic adaptation of the malarial parasite from a strain in which gametocytes occur to one in which they are absent. This has been done under the auspices of the New York State Psychiatric Institute and Hospital by continuous human passage of a sexual strain of malaria.By using a strain of malaria in which no sexual forms are present, the possibility

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