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April 25, 1936

TREATMENT OF GASTRODUODENAL ULCER WITH HISTIDINE MONOHYDROCHLORIDE (LAROSTIDIN)

JAMA. 1936;106(17):1452-1459. doi:10.1001/jama.1936.02770170018008
Abstract

Peptic ulcer constitutes a major problem in medicine. Relatively little is known concerning its etiology and prevention. Symptoms as a rule recur frequently. Medical management is unsatisfactory in a large number of cases. Though the diet-alkali-antispasmodic regimen offers relief to a large percentage of patients, not infrequently, because symptoms continue to recur, the chronic callous ulcer forms with its resultant complications. Surgical treatment is also unsatisfactory. Recurrence of ulcer after operation and gastrojejunal ulcers are not uncommon.

Always alert for a more satisfactory treatment of peptic ulcer, both physicians and patients are not unwilling to try "newer" methods of treatment. Many have been reported in the literature. Chief of the parenteral methods of treatment are vaccineurin,1 novoprotein,2 aolan,3 various strains of organisms and vaccines,4 pepsin,5 sodium benzoate,6 emetine hydrochloride,7 hemoprotein,8 sodium citrate and sodium chloride,9 parathyroid extract,10 insulin11 and histidine

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