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May 9, 1936

EFFECT OF INJECTION OF BACTERIAL FILTRATE ON BROWN-PEARCE RABBIT EPITHELIOMA

JAMA. 1936;106(19):1654-1657. doi:10.1001/jama.1936.02770190030011
Abstract

The employment of bacteria or their products in the treatment of malignant disease is not new. One need only refer to the work of Coley,1 who for some fortyfive years has reported favorably on the use of bacterial preparations in certain neoplasms. More recently Beebe and Tracy2 were able to observe regression and disappearance of transplanted tumors in dogs that had been given injections of bacterial filtrates. Complete destruction of a transplantable mouse tumor was produced by Shear3 in a high percentage of cases with filtrates of Bacillus coli. It is not my purpose here to review the rather extensive literature that has accrued on this general subject. However, reference must be made to the recent publication of Connell,4 since it instigated the present study. Connell reported that symptoms of some patients suffering with carcinoma could be ameliorated by the administration of certain bacterial filtrates containing

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