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May 30, 1936


JAMA. 1936;106(22):1902. doi:10.1001/jama.1936.02770220038015

Since the publication, more than twenty-five years ago, of Moreschi's1 study of the effects of underfeeding in modifying the growth of tumor transplants in mice, many investigators have attempted to determine the possibilities. Even today, however, we continue to ask whether low calory intake can be relied on to delay growth of tumors, postpone the inevitable fatal end to which such growths lead, or retard or hinder the onset of malignant neoplasms that arise spontaneously. Many studies have been inconclusive because "controls" have been fed a diet without relation to that given to the experimental animals with which they have been compared. Indeed, the chief difficulties encountered in interpreting published results of researches on the relation of diet to cancer have been that more than one variable has been studied at a time. This error is illustrated by the common practice of restricting total food intake without making provision

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