Xanthosis in diabetes is due to an accumulation of lipochrome pigments in the blood, the most conspicuous of which has proved to be carotene. Some authors1 explain the hypercarotenemia occurring in diabetes by the increased content of carotene in the diabetic diet; others,2 however, believe that the accumulation of carotene in the blood of diabetic patients is due to a disturbance in the metabolism of carotene which is connected with the metabolic disturbance due to the diabetes. This question deserves more than merely theoretical interest, because the biologic importance of carotene as the precursor of vitamin A is generally accepted.
I have tried to solve the problem by studying the response of the carotene content of the blood in diabetic and in nondiabetic subjects after the administration by mouth of a solution of carotene in oil (0.3 Gm. of carotene per hundred cubic centimeters of oil).
WALTER HEYMANN. CAROTENEMIA IN DIABETES. JAMA. 1936;106(24):2050–2052. doi:10.1001/jama.1936.02770240014005