In 1933 one of us1 described the administration of estrogenic substance as a practical method of treating gonorrheal vaginitis in children. Eight cases treated in this way with marked success were reported. The factwas established that sufficient estrogenic substance given to girls would bring about a temporary maturation of the undeveloped vaginal mucosa. The clinical results in these cases indicated that therapy with estrogenic substance was likely to be successful. Edgar Allen2 had previously described a similar reaction induced in immature monkeys by treatment with estrogenic substance.
Since the publication of this article a number of reports on the results of therapy with estrogenic substance have appeared in the literature.3 With one exception (so far as we know) each author has reported gratifying results.4 Witherspoon5 reported a total of ten cases treated without benefit. He used, however, a relatively small daily or nearly daily dosage of
LEWIS RM, ADLER EL. GONORRHEAL VAGINITISRESULTS OF TREATMENT WITH DIFFERENT PREPARATIONS AND AMOUNTS OF ESTROGENIC SUBSTANCE. JAMA. 1936;106(24):2054–2058. doi:10.1001/jama.1936.02770240018007
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