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June 13, 1936


JAMA. 1936;106(24):2089. doi:10.1001/jama.1936.02770240053023

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To the Editor:—  Ormond (The Journal, May 16, p. 1726) says he has not been able to find reports of the occurrence of bradycardia with hypoglycemia.Manfred Sakel has reported many such observations in the course of his insulin shock treatment of schizophrenia. His publications are a valuable source of data on the clinical manifestations of hypoglycemia. In his monograph "Neue Behandlungsmethode der Schizophrenie," for example (Vienna, Verlag von Moritz Perles, 1935) he states (p. 9) that "a very marked bradycardia sometimes reaching thirty-four beats a minute is characteristic of uncomplicated progressive hypoglycemia." But where there is a strong compensatory epinephrine reaction, or convulsions, he correctly observes, the cardiac response is different.

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