The problem of hemolytic shock is assuming a greater theoretical and practical significance because of the wider adaptation of blood transfusion. Interesting clinical and experimental observations are analyzed by E. P. Gesse1 in a review of twenty-two papers emanating from the First Surgical Clinic and the Research Institute for Blood Transfusion in Leningrad (E. P. Gesse, chief). According to Gesse and his co-workers, hemolytic shock is a complex concept of manifestations on the part of the blood vessels and the heart, accompanied by a depression of the nervous system and caused by transfusion of incompatible blood. They were able to demonstrate in animal experiments that2 depressor substances released from the broken down erythrocytes act directly on the blood vessel wall, causing arterial spasm, dilatation of the capillary bed, stasis and a sharp fall in the blood pressure. The cardiac action is secondarily affected as the result of insufficient flow
HEMOLYTIC SHOCK AFTER BLOOD TRANSFUSION. JAMA. 1936;106(26):2241. doi:10.1001/jama.1936.02770260035013
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