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July 11, 1936

THE TREATMENT OF CHRONIC VARICOSE ULCERSBY MEANS OF ACETYL-BETA-METHYLCHOLINE CHLORIDE IONTOPHORESIS

JAMA. 1936;107(2):114-117. doi:10.1001/jama.1936.02770280024005
Abstract

Chronic ulcers, associated either with varicose veins or with the occlusions following phlebitis of the deep veins, constitute one of the most severe and disabling conditions affecting the lower extremities. Despite the numerous forms of treatment, including vein injection, recommended during the past fifty years, certain of these ulcers fail to heal. This is a report of the results of a new method of treatment of these ulcers, which appears to be more satisfactory than any hitherto suggested.

The formation of varicose ulcers is now generally accepted as being the result of venous stasis, secondary to the dilatation of the veins and weakening of venous valves. This produces an increasing backpressure into the capillary bed, with the development of pressure edema and the waterlogging of the tissues. With the associated anoxemia, impaired nutrition and accumulation of toxic waste products of metabolism, the resistance of the tissues to trauma and infection

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